COVID-19 實驗動物模型
SARS-CoV-2 病毒藉由人類細胞膜上的 ACE2 接受體侵入體細胞，進而造成疾病，針對 COVID-19 的疫苗與藥物研究，需要合適的動物模式加以驗證其有效性與安全性，然而動物實驗中常使用的小鼠與大鼠所攜帶的 ACE2 並無法對 SRAS-CoV-2 有感受性，因此帶有人類 ACE2 的實驗動物對 COVID-19 研究就非常重要，以下為您提供各種人源化 ACE2 小鼠模型。
NSG.K18-hACE2
Stock No: 034901
The addition of the NSG background may result in reduced immune response and increased susceptibility to SARS-CoV viral infection.
K18-hACE2 ; FcRn-/- hFcRn (32) Tg
Stock No: 034902
The Expression of hACE2 and replacement of the expression of mouse FcRn with its human counterpart provides researchers with an accurate prediction of therapeutic monoclonal antibodies to block the spreading of SARS-CoV-2 infection in vivo.
K18-hACE2 ; Ifnar1-
Stock No: 035041
The KO of Ifnar1 may result in reduced immune response and increased susceptibility to SARS-CoV-2 viral infection with the expression of hACE2
hACE2-KI
Stock No: 035000
These mice express hACE2 which the endogenous Ace2 regulatory elements direct expression of hACE2 in place of mouse ACE2 and is floxed.
ACE2-GR/ humanized Ace2 KI
Stock No: 035800
hACE2 gene replaces the endogenous sequence (expression directed by human regulatory elements) and is not floxed.
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