A variety of genetic mutations are known that impair immune functions in mice. Some of these mutant strains are widely used in research on cytokines to study a variety of physiologic and disease processes. Immunodeficient mouse models are useful for understanding mechanisms supporting allogeneic and xenogeneic tumor growth and progression. These mice are used as models of normal hematopoiesis, to study the ontogeny of immune system development, to investigate the growth of lymphomas and leukemic cell types, and to study the influences of cytokines and new therapeutic strategies. Acceptance of multiple tissue xenografts permits these mice to be used also as intermediate models for host-specific, fastidious organisms for which a small animal model has not been available previously.

NU/NU Nude Mouse, Nomenclature Crl:NU-Foxn1^nu

ORIGIN: This immunodeficient nude mouse originated from NIH and was originally thought to be a BALB/c congenic. It was later determined that it was not inbred and is, therefore, maintained as an outbred and is not associated with any stock or strain. The animal lacks a thymus, is unable to produce T-cells, and is, therefore, immunodeficient. To BioLASCO Taiwan in 2007 from Charles River Laboratories.

COAT COLOR:  Hairless, albino background
RESEARCH APPLICATION:tumor biology and xenograft research

BALB/c Nude Mouse, Nomenclature CAnN.Cg-Foxn1^nu/Crl

ORIGIN: Developed through crosses and back-crosses between BALB/cABom-nu and BALB/cAnNCrj at Charles River  Japan (CRJ). Pedigreed pregnant females of CAnN.Cg-Foxn1^nu/Crl were received from CRJ in 1985. This mouse is inbred, and genetic monitoring results confirm it to be a BALB/c nude. The animal lacks a thymus, is unable to produce T-cells, and is therefore immunodeficient. To BioLASCO Taiwan in 2007 from Charles River Laboratories.

COAT COLOR: Hairless, albino background
RESEARCH APPLICATION: tumor biology and xenograft research

Fox Chase SCID^® Mouse, Nomenclature CB17/Icr-Prkdc^scid/IcrCrl

ORIGIN: SCID mice possess a genetic autosomal recessive mutation (scid). Discovered in 1980 by Bosma in C.B-17/Icr mice at Fox Chase Cancer Center. SCID mice show a severe combined immunodeficiency affecting both B and T lymphocytes. They have normal NK cells, macrophages, and granulocytes. To Charles River in 1991 from an Iffa Credo foundation colony. To BioLASCO Taiwan in 2007 from Charles River.

COAT COLOR: White (albino)
RESEARCH APPLICATION: tumor biology and xenograft research

Fox Chase SCID^® Beige Mouse, Nomenclature CB17.Cg-Prkdc^scidLyst^bg-J/Crl

ORIGIN:A congenic mouse that possesses both autosomal recessive mutations SCID (Prkdc^scid) and beige (Lyst^bg). The SCID mutation results in severe combined immunodeficiency affecting both the B and T lymphocytes. The beige mutation results in defective natural killer (NK) cells. This mouse was developed by Croy, et al. at the University of Guelph by an intercross of C.B-17 SCID/SCID to C57BL/6 bg/bg mice. To Charles River in 1993.To BioLASCO Taiwan in 2013 from Charles River.

COAT COLOR: White (albino)
RESEARCH APPLICATION: tumor biology and xenograft research

NOD SCID Mouse, Nomenclature NOD.CB17-Prkdc^scid/NCrCrl

ORIGIN: The SCID mutation has been transferred onto a non-obese diabetic background. Animals homozygous for the SCID mutation have impaired T and B cell lymphocyte development. To Charles River in 2005 from Frederick Cancer Research and Development Center.To BioLASCO Taiwan in 2009 from Charles River Laboratories.

COAT COLOR: White (albino)
RESEARCH APPLICATION: tumor biology and xenograft research